In contrast, the quantification of the area occupied by TH and DAT (dopamine transporter, involved in presynaptic dopamine reuptake) immunostaining showed no difference in the CPu (including DLS, DMS and VLS) and the VST (Acc and Acs) between control and 3xTg-AD mice (Fig. 1d,e, TH staining, genotype: F1,12 = 0.44, p > 0.05; striatal subdivision: F1,12 = 0.74, p > 0.05; genotype × striatal subdivision: F1,12 = 0.66, p > 0.05. Here, TH is linked to Alzheimer disease.