GO analysis showed that the BP of AM-AS compound against DN mainly concentrated in the direction of apoptosis, positive regulation of RNA polymerase II promoter transcription, hypoxia response, inflammatory response, etc. The main pathways obtained by KEGG analysis include PI3K-Akt signaling pathway, TNF signaling pathway, NF-κB signaling pathway, MAPK signaling pathway, HIF-1 signaling pathway, FOXO signaling pathway, etc. 31 pathways contain IL-6, such as HIF-1 signaling pathway and insulin resistance pathway, etc. 104 target genes connect closely with IL-6. The gene discussed is NFKB1; the disease is Insulin resistance.