Consistent with previous studies45–47 in vivo models (arthritis rat model, tumor mouse model), our data demonstrated disrupted collagen cross-linking (Figs. 4, Supplementary Fig. S2 online) affecting collagen I, II and IV (Fig. 5) resulting in non-cross-linked Cfl and amorphous ECM (Figs. 4, Supplementary Fig. S2 online). The gene discussed is CFL1; the disease is Arthritis.