Given the central role of GR signaling in mediating clinical response to GC therapy in MS (via regulation of inflammation and apoptosis), in the present study we measured key GR-target genes such as GILZ, MCL-1 and NOXA in MS patients during relapse and evaluated whether any of the abovementioned genes could be considered as markers of the MP treatment response. This evidence concerns the gene NR3C1 and myeloid sarcoma.