DEFA4 and myeloid sarcoma: In line with our investigation, De Anders et al., examined the expression of several genes in CD4 T lymphocytes of MS patients in relapse after MP treatment and found seven genes to be upregulated (DEFA4, CTSGI, DEFA8P, AZU1, MPO, ELANE, PRTN3) and four genes downregulated (IFNG, TNF, ZNF683) after IVMP administration27.