The optimized prediction model included age, body mass index, presence of respiratory disease, presence of renal disease, BNP, IL-6, C reactive protein, ferritin, stroke volume index, free-wall right ventricular strain, total right ventricular strain, left atrial pump strain, LV GLS, right atrial pressure, pulmonary artery systolic pressure, and average E/eʹ ratio. The gene discussed is NPPB; the disease is respiratory system disorder.