THPO and anemia (phenotype): This immune response is complemented by the IL-6 regulated JAK-STAT3 signaling pathway, which controls cytokines like erythropoietin, thrombopoietin and G-CSF and thereby may be involved in dealing with pathological conditions like anemia, thrombocytopenia, and neutropenia or, alternatively, the generation of antibodies through B-cell and plasma cell differentiation.