CACNA1D and Hypertension resistant to conventional therapy: In addition, our data suggest that CYP11B2 (the aldosterone synthase gene) and CACNA1D (a member of the voltage-gated calcium channel gene family), which are known to be associated with hypertension, may be involved in the development not only of hypertension, but also of resistant hypertension, and underline the importance of these loci in resistant hypertension.