Gene-based tests identified 21 genes associated with resistant hypertension, including GBX1, AGAP3, ASB10, ABCF2 and TMUB1 on chromosome 7q36, ESRP1 and LOC100288748 on 8q22, CYP11B2, CYP11B, GML, LY6D, LYNX1_1, LYNX1_2 and LOC100133669 on 8q24, DLGAP1, DLGAP1-AS3, DLGAP1-AS4 and MIR6718 on 18p11, ERG on 21q22, and GAB4 and CECR7 on 22q11. The gene discussed is GAB4; the disease is Hypertension resistant to conventional therapy.