PDGFRA and Anxiety: Indeed, we found that mice spent significantly less time in the center zone of the open field arena (Fig. 6e, f, n = 6 mice at postnatal 8–12 weeks for Pre-CSDS and Post-CSDS group; n = 12 mice at postnatal 8–12 weeks for Pdgfrα+;ChR2+ and Pdgfrα+;ChR2− each group), and this heightened anxiety in CSDS was further supported by their spending less time exploring the open arms in EPM test (Fig. 6g, h, n = 6 mice at postnatal 8–12 weeks for Pre-CSDS and Post-CSDS group; n = 12 mice at postnatal 8–12 weeks for Pdgfrα+;ChR2+ and Pdgfrα+;ChR2− each group).