CCL2 and neoplasm: In line with this, reduced CCL2 expression in the tumor tissue was found in the DEN/CCl4-induced (Fig. 3B, Supplementary Fig. 4G, 4E), CCl4-induced (Supplementary Fig. 4C) and DEN/HFD-induced HCC model (Supplementary Fig. 4D) under EE housing condition compared to SE.