CD4 and neoplasm: While EE was still responsible for tumor growth after CD4+ T cell and NK cell depletion (Supplementary Fig. 2C, F), CD8+ T cells depletion abolished the antitumor effect of EE on Hepa1-6 (Fig. 2F), H22 (Fig. 2G) LPC-H12 (Fig. 2H), and DEN + CCl4 (Fig. 2I) tumor models.