As expected, in SE mice, either depletion of TAMs with clodronate liposomes (Supplementary Fig. 2D) or G-MDSCs with Ly6G-antibody (Supplementary Fig. 2E) inhibited the tumor growth and induced the infiltration of CD8+ T cell (Supplementary Fig. 3D), mimicking the action of EE (Supplementary Fig. 2D, E). The gene discussed is CD8A; the disease is neoplasm.