Similarly to HCC, the expression of ADRB1 and ADRB2 were also significantly reduced across multiple types of human tumors such as breast cancer (BARC), cholangiocarcinoma (CHOL), colon cancer (COAD and READ), lung cancer (LUAD and LUSC, Supplementary Fig. 9 A, B). This evidence concerns the gene ADRB1 and cholangiocarcinoma.