As is exhibited in Fig. 5b, c and Supplementary Figs. 23–26, weak ferroptosis of HACA-Fe hardly affected the tumor development; however, arming this function with tumor exosome elimination improved the therapeutic result remarkably, which was evidenced by the apparent difference of tumor inhibition induced by HACA-GW and HGF, respectively. This evidence concerns the gene MASTL and neoplasm.