WNT10A binds to the Frizzled transmembrane receptor (G protein-coupled receptor that serves to transduce extracellular signals into cells32 and to LRP6 (lipoprotein receptor-related protein 6) co-receptor, leading to the activation of the Wnt/β-catenin pathway.33WNT10A mutations are predicted to disrupt or reduce Wnt-mediated signaling.34 resulting in a deficiency of Wnt/β-catenin activity and arrest of tooth development.35 In contrast, increased expression of WNT10A results in upregulation of the β-catenin pathway, which may lead to cancers.32 Here, LRP6 is linked to cancer.