In this pathway, the EDA receptor (EDAR) binds to its adapter (EDARADD) and forms an EDA-EDAR-EDARADD complex that leads to the downstream activation of NF-κB signaling.15,29 Additionally, during tooth development, EDA may regulate the expression of WNT10A, WNT10B, and BMP4 via NF-κB.30 Interestingly, despite a close relationship between EDA and EDAR, when these genes are mutated the resulting patterns of oligodontia are distinct.31 The gene discussed is BMP4; the disease is Oligodontia.