These findings are consistent with previous reports which established WNT10A variants accounting for up to 50% of various ED syndromes with missing teeth.52 ED caused by WNT10A mutations often include hypohidrotic ectodermal dysplasia (HED), odonto-onycho-dermal dysplasia (OODD) syndrome, and Schopf-Schulz-Passarge syndrome (SSPS). This evidence concerns the gene WNT10A and odonto-onycho-dermal dysplasia.