The agenesis of anterior teeth is more likely linked to EDA mutations.24,27EDA encodes ectodysplasin A, a transmembrane protein of the TNF family involved in the EDA/EDAR/NF-κB signaling pathway required for normal embryogenesis, particularly of ectodermal organs including tooth, hair, and skin.28 In our review, four cases showed syndromic phenotype including sparse or curly hair, wrinkled skin, or heat intolerance. This evidence concerns the gene TNF and hypohidrotic ectodermal dysplasia.