WNT10A and Oligodontia: A dosage-dependent pattern has been suggested when it comes to the phenotype caused by WNT10A mutations.36 Individuals with biallelic WNT10A mutations generally present with more severe tooth agenesis when compared to individuals in the same family with defects in a single allele.37 Heterozygous WNT10A variants resulting in variable penetrance and expressivity has been observed in many studies.37,38 These observations are consistent dental phenotypic features observed in the oligodontia subjects of the seven families with WNT10A mutations reported here.