While at odds with the Lp(a) literature to date, this observation is consistent with other data demonstrating that while traditional cardiovascular risk factors (eg, LDL-cholesterol) are associated with new-onset incident AVC, they show no relation with disease progression after correction for baseline AVC score.22 23 Further studies are now required to resolve this apparent discrepancy and also whether the relationship between Lp(a) and disease progression depends on baseline AS severity. Here, LPA is linked to aortic valve stenosis.