This was first demonstrated in a post-hoc analysis of the Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER) trial, which evaluated the effect of statin treatment in relatively young patients (mean age 58 years) with mild to moderate AS.21 Elevated Lp(a) levels were associated with more rapid haemodynamic AS progression on echocardiography over a median follow-up of 3.5 years, especially in younger patients (<57 years, median). This evidence concerns the gene LPA and aortic valve stenosis.