Work by Nam et al evaluating the feasibility of mpMRI prostate as a screening test for prostate cancer, irrespective of PSA level, detected MRI score 4 or 5 lesions in 17 of 47 (36%) men.13 If we assume half this prevalence rate (15%) in men who consent to ReIMAGINE Screening, as they are selected randomly via GP practices, rather than via a newspaper advert, we will require 300 MRIs in order to identify 45 men with MRI score 4 or 5 lesions. Here, KLK3 is linked to prostate cancer.