Of relevance, internalization of extracellular tau by microglia and astrocytes is mediated by fractalkine receptor and Transcription Factor EB, respectively [6, 41] , and astrocytic complement C3 and its microglial receptor C3aR mediates neuronal tau pathology in AD brain and PS19 transgenic mice [39]. The gene discussed is CX3CR1; the disease is Alzheimer disease.