METTL3 and neuroblastoma: Significant reduction of endogenous METTL3 protein level was confirmed by western blot analysis in mouse neuroblastoma N2a cells (Fig. 3 B) and rat primary neurons (not shown) transiently transfected with AAV vector containing shMettl3 as compared to cells transfected with AAV vector containing a scramble shRNA as a negative control (shCtrl).