Given that constitutive HIF1A expression varied drastically amid ccRCC cells, we overexpressed HIF1A in 786O and A498 cells with low basal HIF-1α level, and silenced HIF1A expression in Caki1 and RCC4 cells with high basal HIF-1α level. This evidence concerns the gene HIF1A and nonpapillary renal cell carcinoma.