CASP3 and colorectal carcinoma: In addition, flow cytometry assay and caspase-3/8/9 activity analysis were adopted to testify the impact of RAB22A inhibition on cell apoptosis, and it was shown that the apoptosis rate of HCT15 and SW116 cells and the activity of caspase-3/8/9 were enhanced upon RAB22A silencing, which showed that RAB22A knockdown could effectively enhance CRC cell apoptosis (Fig. 4O-P and Supplementary Fig. 2F).