BCHE and early-onset autosomal dominant Alzheimer disease: To this effect, the role of multi-target drug candidates for multi-functional Alzheimer’s disease using cholinesterase inhibition and others, for example N-methyl-D-aspartic acid receptor (NMDAR), as molecular targets has been explored [19, 20, 47]; however, several challenges which include undesirable side effects, incessant incidence of drug resistance, and reduced efficacy against diseases for which pathogenesis relies on many biochemical events and bioreceptors working concomitantly necessitate the need for the design of sensitive drugs with specific targets [31].