ACHE and Neurofibrillary tangles: It is believed that improper folding of tau proteins causing beta-amyloid plaques and neurofibrillary tangle, overproduction of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), resulting in low stimulation of neurons and depletion of the antioxidant system caused by the ‘brain’s radical-induced damage due to the low level of antioxidant enzymes and high dependency on oxygen are the major causes of the disease [27].