Oil red O staining of aortic root sections and whole aorta also demonstrated reduced atherosclerotic lesions area in HMD‐fed ApoE−/− mice injected with Lv‐miR‐195‐3p (Figure 2j and Figure S1i), indicating miR‐195‐3p overexpression protects mice from the development of atherosclerosis. Here, APOE is linked to atherosclerosis.