The greater number of genes that were significantly induced in the Ifnar1-/- mice in this second transcriptome study compared to that shown in Fig 1 reflects the use of a more potent viral inoculum (HM175-mp6 vs. HM-175-mp10), a greater length of time since infection (14 versus 7 days), and consequently more severe liver injury (mean serum ALT 195 IU/L versus 107 IU/L). Here, GPT is linked to infection.