Genes encoding interferons (Ifnb, Ifnl2 and Ifnl3), chemokines (Ccl7, Ccl5, and Cxcl10), and ISGs (Ifit1, Ifit2, Ifit3b, Oas3, Ifi44, Rsad2, and Isg15, among others) were prominently represented among those induced by infection in Ifnar1-/- mice (Fig 1F and 1H and S1B Table). Here, ISG15 is linked to infection.