However, because DYT1 dystonia alters protein trafficking, the expression level of RGS9–2 is selectively increased in the fraction of DRM where D2Rs is located [28,55], and the perpendicular change appeared in the space of D2R and RGS9–2 (Fig 3D, red points). Here, RGS9 is linked to early-onset generalized limb-onset dystonia.