RGS9 and early-onset generalized limb-onset dystonia: By contrast, a mouse model of DYT1 dystonia shows the decrease and increase in D2R and RGS9–2, respectively, in the co-existent fraction of D2R and RGS9–2 (DRM; Fig 3E, red points) [28], and the increased GTP hydrolysis may be related to involuntary movements.