Single-cell trajectories as derived from pseudotime analyses of a xenograft mouse model for melanoma treatment with the BRAF inhibitor dabrafenib showed that an early proliferative state developed via 2 different developmental trajectories into 2 types of highly proliferative stem cells, namely neural crest-like and starved-like melanoma cells, which are enriched in a minimal residual disease (MRD) state34. Here, BRAF is linked to melanoma.