Cells in C3 upregulated mainly spot (module) D, which enriches p53 targets, signature genes of the epithelial–mesenchymal transition, stroma-associated genes, and KDM5B, an epigenetic marker of slow cycling in melanomas known to associate with drug resistance (Figure 3A, Table 1 and Figure 2F)23,24. Here, TP53 is linked to melanoma.