Consistently, immunohistochemical staining of specimens from in vivo tumor nodules demonstrated that the protein levels of p-ERK1/2, β-catenin, cyclin D1, c-Myc, and N-cadherin were diminished, and the protein level of E-cadherin was increased by SHP-1 (Supplementary Figure S3B). The gene discussed is PTPN6; the disease is neoplasm.