Consistently, cleaved-caspase3 (c-casp3) was dramatically reduced in the DU145 PCa cell line expressing high levels of E-cadherin (DU-H) upon camptothecin (CPT) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) treatments, when compared to E-cadherin low DU145 (DU-L). The gene discussed is CDH1; the disease is posterior cortical atrophy.