Case 5 had marked changes in status from the first to the second trimesters, developing severe hypertension (BP changed from 108/73 to 175/105 mmHg) and severe malnutrition (BUN from 63 to 35 mg/dL, albumin from 3.2 to 2.2 mg/dL, and phosphate from 5.1 to 2.5 mg/dL). The gene discussed is ALB; the disease is hypertensive disorder.