HIF1A and pachyonychia congenita: Tiwari et al. demonstrated that in PC, hypoxia-inducible factor 1 alpha (HIF1α) acts as a tumor suppressor by suppressing the expression of protein phosphatase 1 regulatory subunit 1B (PP1R1B), leading to the degradation of p53 protein in pancreatic cancer cells and an increase in the invasive and metastatic activity of tumors cells [27].