CDKN2A and pachyonychia congenita: The primary driver gene mutations of PC, including KRAS, TP53, p16/CDKN2A, and SMAD4, have a crucial role in early pancreatic lesions, local and advanced tumors, metastasis, and the hypovascular and hypoxic nature of the stroma, which contributes to the evasion of the immune response and alterations in cellular metabolism [24–26].