The enriched pathways for integrin binding, laminin-binding, ECM disassembly, and PI3K-AKT signaling pathway in PC further emphasize the metastatic involvement of ARNTL2, as they are associated with invasion and metastasis, and there is a link between TGF-β and PI3K-AKT signaling pathways, demonstrated by crosstalk in cancer [85, 87]. The gene discussed is TGFB1; the disease is pachyonychia congenita.