Administration of an unconjugated heavily modified single-stranded anti-miR-21 antisense oligonucleotide in the K-Ras-driven p53-mutated KPC model at an early age is remarkably effective at preventing tumor progression from pancreatic intraductal precursor lesion to malignant invasive carcinoma in this aggressive GEMM [141]. Here, TP53 is linked to neoplasm.