Despite these evidences of CSF_Tau variables as key biomarkers in AD progression, their effects on cognition seemed to be observed only when considering MCI and AD subjects or when including all diagnoses of the ADNI dataset [57, 59, 61, 62], and not when looking only at the normal-cognition controls, as it is the case in our report. The gene discussed is MAPT; the disease is Alzheimer disease.