ECT2 and Global developmental delay: For example, it is unclear whether sequence determinants in addition to m6A are important for mRNA target association of ECT proteins in vivo, the mRNA targets of ECT2/ECT3/ECT4 responsible for the developmental delay of ect2/ect3/(ect4) mutants have not been identified, and it is not clear what the effects of ECT2/ECT3/ECT4 binding to them may be (Arribas-Hernández and Brodersen, 2020).