These data demonstrate that the level of total H2A.Z present in the cell, as well as the percentage of H2A.Z that is acetylated is significantly impacted by the loss of Elp1. Finally, to determine whether H2A.Z upregulation is unique to Wnt1-Cre; Elp1LoxP/LoxP knockouts, we also quantified H2A.Z in pooled retinas from Pax6-Cre; Elp1LoxP/LoxP mice that exhibit progressive retinal degeneration (Ueki et al., 2018). This evidence concerns the gene WNT1 and retinal degeneration.