In the EMT in the CRC pathway, proteins such as fibronectin (FN1), vitronectin (VTN), mothers against decapentaplegic homolog 2 (Smad2), neurogenic locus notch homolog protein 1 (Notch1), MAGUK p55 subfamily member 5 (MPP5), and SHC transforming protein 1 (SHC1), which promoted EMT, were all specifically upregulated in RNMC (Figure 3B). Here, SMAD2 is linked to colorectal carcinoma.