In an analysis of the protein composition of serum-derived extracellular vesicles (EVs) in LNMC and RNMC, Zhong et al. found that LRG1 and SPARC were increased in serum-derived EVs of colon cancer, with a higher abundance in RNMC than in LNMC, indicating that these proteins are potential markers that can be used to predict the prognosis and recurrence of colon cancer [39]. The gene discussed is LRG1; the disease is malignant colon neoplasm.