Indeed, mutations of genes implicated in epigenetic regulation such as KMT2D (MLL2, one of the most frequently mutated genes in NMZLs), ARID1A, EP300, CREBBP, and TBL1XR1 are well known in other MZL, and some of them are described in SMZL too. This evidence concerns the gene CREBBP and marginal zone lymphoma.