Autoimmune disorders (autoimmune hemolytic anemia, cryoglobulinemia, idiopathic thrombocytopenic purpura, and others) are frequent, as well as monoclonal components (mostly Immunoglobulin M (IgM), classically with levels of <3 g/dL in about 50% of the cases) [8]. The gene discussed is CD40LG; the disease is autoimmune disease.