Among the miRNA with reduced expression in SMZL, nine can target CAV1, including miR-199a, miR-376, and miR-485, and may promote tumor progression by inducing the overactivation of transcriptional factors (IGF1R for miR-376a; IKKβ and NFκB pathway for miR-199a) [33]. This evidence concerns the gene IGF1R and neoplasm.