The low level of serum testosterone can be achieved by bilateral orchiectomy, radiotherapy or androgen deprivation therapy (ADT) which is indicated in locally advanced disease (defined by T3-T4), N1, metastatic disease, non-metastatic castration-resistant disease and high-risk localized disease (defined by T3a or Gleason Score 8–10 or PSA (Prostate-specific antigen) > 20 ng/mL) [6]. Here, KLK3 is linked to metastatic neoplasm.