ZNRF3 and lung adenocarcinoma: To screen these 18 PTKs, we utilized H1703 human lung adenocarcinoma cells harboring doxycycline (Dox)-inducible ZNRF3-HA (TetOn ZNRF3-HA) to overcome poor transfection efficiency of this cell line as well as the general lack of antibodies against endogenous ZNRF3 (Chang et al., 2020).