Invasive pseudopods that we defined in these pancreatic cancer cells highly expressing ARL4C consisted of similar molecules, including cortactin, ARPC2, IQGAP1, and MMP14, which are involved in invadopodia functions (Caswell and Zech, 2018; Jacquemet et al., 2013; Murphy and Courtneidge, 2011). Here, CTTN is linked to familial pancreatic carcinoma.