AKT1 and nervous system disorder: 2014) that differ in terms of regulation and the preferred lipid substrate. PI3K lipid kinases are involved in many cellular functions, including signal transduction and intracellular vesicular trafficking; PI3K pathway dysregulation is a feature of several pathological conditions, including neurological diseases. PI3K/Akt pathway inhibition in LPS-activated microglia reduced the levels of proinflammatory factors (Zhou et al. 2020).