In patients experiencing a manic episode, pro‐inflammatory cytokines (e.g., TNF‐α, IL‐1, IL‐6), soluble receptors of IL‐2, soluble TNF‐α receptor type 1 (sIL‐2R and sTNFR1, respectively), and C reactive protein (CRP) are generally increased when compared to a control population.1, 2, 3. This evidence concerns the gene IL1B and manic or hypomanic episode.