A recent systematic review and meta‐analysis finally confirmed altered peripheral markers in BD, according to which IL‐6 seems to be a trait marker for BDs, while CRP and TNF‐α could constitute state markers, as they are increased during mood episodes,33 a feature that could also represent a fruitful entry‐point for the prevention of suicide attempts.34 This evidence concerns the gene CRP and Diamond-Blackfan anemia.