Consistently, Zhang et al33 recently showed that the caspase‐8, which is recruited to ROS‐oxidized and internalized death receptor 6 (DR6) after application with dimethyl‐α‐ketoglutarate (DM‐α‐KG), can cleave GSDMC at Asp240 and subsequently trigger GSDMC‐mediated pyroptotic cell death in many human gastric cancer cells (SGC‐7901 and BGC‐823), human colon cancer cells (HCT116) and human hepatoma cells (Huh7). The gene discussed is TNFRSF21; the disease is hepatocellular carcinoma.