Recently, Hou J and his colleagues indicated that GSDMC‐mediated pyroptosis in cancer cells, which is activated by PD‐L1 (programmed cell death ligand 1)‐STAT3 (signal transducer and activator of transcription)‐caspase‐8 signalling pathway under hypoxia, exacerbates chronic inflammatory necrosis in the nearby tumour microenvironment and subsequently promotes tumour angiogenesis, eventually fuelling tumour progression in vivo.32 The gene discussed is CD274; the disease is cancer.