Endogenous miR‐135b, which is downregulated in PD, suppresses MPP+‐induced pyroptosis through inhibiting FOXO1 (Forkhead Box Protein O1) /TXINP (Thioredoxin Interacting Protein)/ NLRP3/caspase‐1/GSDMD/pyroptosis axis. This evidence concerns the gene NLRP3 and Parkinson disease.