We rated the quality of evidence for Hb, ferritin, and sTfR concentrations, as well as anemia, moderate-to-severe anemia, iron deficiency, elevated sTfR, and IDA, as high, based on the GRADE criteria listed in the Methods: ≥6 RCTs were available for these outcomes and the total sample size was roughly >2500, the risk of bias was low, all trials were directly aimed at evaluating SQ-LNSs, funnel plots revealed no indication of publication bias, and the direction of the effect was consistent even though the magnitude of the effect across trials differed (i.e., moderate to high heterogeneity). The gene discussed is TFRC; the disease is anemia (phenotype).