Employing sevoflurane as a clinically relevant tool, and WT, Tau KO, IL-6 KO, and CypD KO young mice as the approaches, we demonstrated the interactions of Tau phosphorylation, IL-6 accumulation and mitochondrial dysfunction and the effects of such interactions on synapse number and cognitive impairment in young mice. This evidence concerns the gene MAPT and Cognitive impairment.