MAPT and Cognitive impairment: However, the objective of the current studies was not fully characterizing the effects of sevoflurane on Tau phosphorylation but rather using the Tau-PS202/PT205, as a representative, to determine the interactions of Tau phosphorylation, IL-6 elevation, and mitochondrial dysfunction, and to assess whether such interactions can cause synaptic loss and cognitive impairment in young mice.