It is possible that TA did not suppress IFN-γ secretion by MLN lymphocytes because it precipitates on top of the colon and does not penetrate into the colon tissue (de Jesus et al., 2012), resulting in the suppression of Th17 responses since Th17 preferentially accumulates on the colon membrane rather than Th1 in experimental colitis in mice. The gene discussed is IFNG; the disease is colitis.