There were no differences noted between patients with low to deficient levels of PLP compared to those with normal levels with regard to age, sex, BMI, smoking, education, depression severity, depression subtype, presence of diabetes or cardiovascular disease, NSAID use, response to ECT, or the weight loss question (Item 5) on the HAMD-24 scale (Table 3). This evidence concerns the gene PDXP and major depressive disorder.