CRP and depressive symptom measurement: For instance, adipose tissue is responsible for approximately 30% of circulating IL-6, which directly stimulates CRP (Mohamed-Ali et al., 1997), and also is linked to depression (Quek et al., 2017); thus, does examining the relationship of CRP and depression adjusted for adiposity misrepresent the potentially causal relationship linking adiposity and depression via inflammation (Berk et al., 2013)?