Indeed, work by our group has demonstrated that adiposity, stress exposure, early life adversity, and sedentary behavior are all linked to cognitive dysfunction in youth and present in depression (Mac Giollabhui et al., 2019, Giollabhui et al., 2021), with one study identifying interleukin-6 as the mediator linking adiposity with executive dysfunction (Mac Giollabhui et al., 2020c). Here, IL6 is linked to depressive disorder.