For instance, adipose tissue is responsible for approximately 30% of circulating IL-6, which directly stimulates CRP (Mohamed-Ali et al., 1997), and also is linked to depression (Quek et al., 2017); thus, does examining the relationship of CRP and depression adjusted for adiposity misrepresent the potentially causal relationship linking adiposity and depression via inflammation (Berk et al., 2013)? Here, IL6 is linked to major depressive disorder.