LPS associated with altered expression of HCN1 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 1); previous studies have shown LPS-induced neuroinflammation associates with reduced HCN1 and altered HCN1 function leads to abnormalities implicated in hyperexcitability and cognitive deficits (Frigerio et al., 2018; Marini et al., 2018). The gene discussed is HCN1; the disease is Cognitive impairment.