TNF and relapsing-remitting multiple sclerosis: The increase of pro-inflammatory cytokines interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) prior to and during clinical relapse have been widely demonstrated in the literature in relapsing-remitting MS (RRMS) compared to controls (Imitola et al., 2005).