Survival analysis using the Cox regression model showed that VSR medical management, non-revascularization therapy, advanced age, concomitant CS, acute VSR type, complicated with ventricular arrhythmia, lower systolic blood pressure and left ventricular eject fraction, higher level of log NT-proBNP, log CTNI, log CK-MB, log LDH, log AST, white blood cell count, and estimated glomerular filtration rate <60 mL/min/1.73 m2 were univariate predictors of the long-term mortality. The gene discussed is NPPB; the disease is Ventricular arrhythmia.