Furthermore, another report showed that periodontal treatment of NAFLD/NASH patients decreased ALT and AST levels, while intravenous administration of P. gingivalis significantly increased body and liver weights, and elevated ALT and TG in a mouse model of NAFLD induced by a high fat diet (Yoneda et al., 2012), consistent with our observations. This evidence concerns the gene GPT and metabolic dysfunction-associated steatohepatitis.