This peptide is usually detoxified during the transport in healthy subjects, whereas in active CD patients most of these peptides are transported intact in the serosal compartment; this process may be explained by the binding between gluten peptides with anti-gliadin secretory IgA finally forming large complexes in the intestinal lumen which in turn bind the CD71 receptor, namely the endocytic receptor for transferrin, thus activating the transport across enterocytes escaping lysosomal degradation (156). The gene discussed is CD79A; the disease is Cowden disease.