It was reported that serum levels of IL-33 and sST2 were elevated in patients with active AOSD; and serum IL-33 levels correlated with systemic score, ESR, ferritin levels, and aspartate transaminase levels, while serum soluble ST2 levels correlated only with ferritin levels (94). The gene discussed is IL1RL1; the disease is adult-onset Still disease.