IL-33 and sST2 levels were increased in the serum of SLE patients.  IL-33 neutralization had a protective effect in MRL/lpr mice, which was associated with the increase of regulatory T cells and myeloid-derived suppressor cells and the reduction of Th17 cells and pro-inflammatory factors.  IL-33 might be involved in innate lymphoid cell disorder in the peripheral blood of SLE patients. This evidence concerns the gene IL33 and systemic lupus erythematosus.