A growing number of studies have demonstrated a critical role of the IL-33/ST2 axis in rheumatic diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), primary Sjögren's syndrome (pSS), systemic sclerosis (SSc), psoriatic arthritis (PsA), gout, IgG4-related diseases, and ankylosing spondylitis (AS), indicating a promising potential for IL-33/ST2-targeting therapy in rheumatic disease (10). The gene discussed is IL1RL1; the disease is immunoglobulin G4-related sclerosing disease.