Furthermore, CASP8 (2%), NLRC4 (1%), NLRP3 (1%), NLRP2 (1%), PLCG1 (1%), NLRP1 (1%), NLRP7 (1%), SCAF11 (1%), GSDMC (1%), and NOD1 (1%) occurred somatic mutations as well as most of them had high frequencies of CNV in breast cancer. The gene discussed is CASP8; the disease is breast cancer.