Among pyroptosis-related genes, GPX4, NLRP7, CASP6, CASP3, IL1B, IL18, CASP8, NLRP6, IL6, GSDMC, PYCARD, AIM2, NOD2, NLRP3, and CASP4 were aberrantly expressed in breast cancer. This evidence concerns the gene GPX4 and breast cancer.