The low RS breast cancer samples were characterized by increased expression of human lymphocyte antigen (HLA), as follows: HLA-E, HLA-DPB2, HLA-C, HLA-J, HLA-DQB1, HLA-DQB2, HLA-DQA2, HLA-DQA1, HLA-A, HLA-DMA, HLA-DOB, HLA-DRB1, HLA-H, HLA-B, HLA-DRB5, HLA-DOA, HLA-DPB1, HLA-DRA, HLA-DRB6, HLA-L, HLA-F, HLA-G, HLA-DMB, and HLA-DPA1 (Figure 6B). The gene discussed is HLA-DQB2; the disease is breast cancer.